Zukaria
Generic name: Asenapine Maleate
5 mg
Manufactured by: Incepta Pharmaceuticals Ltd.
Unit Price: ৳ 30.00 (3 x 10: ৳ 900.00)
Strip Price: ৳ 300.00
Asenapine is indicated for:
- Schizophrenia in adults
- Bipolar I disorder
- Acute monotherapy for manic or mixed episodes in adults and pediatric patients 10 to 17 years of age
- Adjunctive treatment to lithium or valproate in adults.
- Maintenance monotherapy treatment in adults
The mechanism of action of asenapine, in schizophrenia and bipolar I disorder, is unknown. It has been suggested that the efficacy of asenapine in schizophrenia could be mediated through a combination of antagonist activity at D2 and 5-HT 2A receptors.
Asenapine should be used with caution in combination with:
- Antihypertensive, as it may cause hypotension
- Paroxetine (CYP2D6 substrate and inhibitor)
The most common adverse reactions to asenapine are akathisia, somnolence, oral hypoesthesia, dizziness, extrapyramidal symptoms, nausea, increased appetite, fatigue, and increased weight.
May cause extrapyramidal and/or withdrawal symptoms in neonates with third trimester exposure. Lactation studies have not been conducted to assess the presence of asenapine in human milk, the effects of asenapine on the breastfed infant, or the effects of asenapine on milk production.
Caution should be exercised when asenapine is prescribed in elderly patients with dementia-related psychosis, QT prolongation, neuroleptic malignant syndrome, tardive dyskinesia, metabolic changes, orthostatic hypotension, leukopenia, neutropenia, agranulocytosis, seizures, and the potential for cognitive and motor impairment.
There is no specific antidote for asenapine. The management of overdose should concentrate on supportive therapy, maintaining an adequate airway, oxygenation and ventilation, and the management of symptoms. In cases of severe extrapyramidal symptoms, anticholinergic medication should be administered. Close medical supervision and monitoring should continue until the patient recovers.
Do not store above 30°C. Keep away from light and out of the reach of children.
Alternative Brand Names
No data was found