The total daily dose of this solution depends on the patient’s metabolic requirement and clinical response. The nitrogen content and caloric values of this infusion are-
- Amino Acid Chamber (250 ml): 4.2 g
- Dextrose Chamber (250 ml): 710 Kj (170 Kcal)
Recommended dietary allowances of protein range from approximately 0.8 g/Kg of body weight for adults to 2.2 g/Kg for infants. Daily amino acid doses of approximately 1.0 to 1.5 g/Kg of body weight for adults and 2 to 3 g/Kg of body weight for infants with adequate calories are generally sufficient to satisfy protein needs and promote positive nitrogen balance.
In fluid restricted patients (eg. Renal failure), acceptable total daily administration volumes are dependent upon the fluid balance requirements of the patients.
Depending upon the clinical condition of the patient, approximately 3 litres of solution may be administered per 24 hour period. When used post-operatively, the therapy should begin with 1000 ml on the first post-operative day. Thereafter, the dose may be increased to 3000 ml per day.
The total daily dose of this solution depends on the patient’s metabolic requirement and clinical response. The nitrogen content and caloric values of this infusion are-
- Amino Acid Chamber (250 ml): 4.2 g
- Dextrose Chamber (250 ml): 710 Kj (170 Kcal)
Recommended dietary allowances of protein range from approximately 0.8 g/Kg of body weight for adults to 2.2 g/Kg for infants. Daily amino acid doses of approximately 1.0 to 1.5 g/Kg of body weight for adults and 2 to 3 g/Kg of body weight for infants with adequate calories are generally sufficient to satisfy protein needs and promote positive nitrogen balance.
In fluid restricted patients (eg. Renal failure), acceptable total daily administration volumes are dependent upon the fluid balance requirements of the patients.
Depending upon the clinical condition of the patient, approximately 3 litres of solution may be administered per 24 hour period. When used post-operatively, the therapy should begin with 1000 ml on the first post-operative day. Thereafter, the dose may be increased to 3000 ml per day.
- Patients with acute renal failure.
- Patients with severe liver disease or hepatic coma.
- Hypersensitivity to one or more amino acids.
- Inborn errors of amino acid metabolism concerning one or more amino acid components.
- Proper administration of this injection requires a knowledge of fluid and electrolyte balance and nutrition as well as clinical expertise in recognition and treatment of the complications which may occur. The IV administration of this solution can lead to fluid or solute overload resulting in hyper or hypoosmolal states. The risk of hypoosmolal states is especially present in conditions associated with ADH secretion and is proportional to the infusion rate.
- Administration of amino acid solution to a patient with hepatic insufficiency may result in serum amino acid imbalances, hyperammonemia, stupor and coma. Conservative doses of this injection should be given to patients with known or suspected hepatic dysfunction. Should symptoms of hyperammonemia develop, administration should be discontinued and the patient’s clinical status should be reevaluated.
- Administration of amino acid solution in the presence of impaired renal function presents special issues associated with retention of electrolytes.
- This solution should not be administered simultaneously with blood through the same infusion set because of the possibility of pseudoagglutination.
- With the administration of this injection; hyperglycemia, glycosuria and hyperosmolar syndrome may result. Blood and urine glucose should be monitored on a routine basis in patients receiving this therapy.
- Parenteral nutrition mixtures should be withdrawn slowly as sudden cessation in administration of a concentrated dextrose solution may result in rebound hypoglycemia due to continued endogenous insulin production.
- Special care must be taken when giving hypertonic dextrose to patients with impaired glucose tolerance such as diabetics or prediabetics and uremic patients.
- Handling of gulcose load is also frequently imparied in patients with liver failure.
- Caution must be exercised when administering this injection to patients receiving corticosteroids or corticotropin.
- Hold the bag at the top (hanging hole end).
- Roll the bag so that maximum liquid is pushed to the bottom of the bag (tube end).
- Press the bag with two fists so that the liquid flows to the tube end.