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Gadoteric Acid

Gadoteric acid is indicated for intravenous use with magnetic resonance imaging (MRI) in brain (intracranial), spine and associated tissues in adult and pediatric patients (2 years of age and older) to detect and visualize areas with disruption of the blood brain barrier (BBB) and/or abnormal vascularity.

Gadoterate is a paramagnetic molecule that develops a magnetic moment when placed in a magnetic field. The magnetic moment enhances the relaxation rates of water protons in its vicinity, leading to an increase in signal intensity (brightness) of tissues. When placed in a magnetic field, gadoterate shortens the T1 and T2 relaxation times in target tissues.
For adult and pediatric patients (including term neonates), the recommended dose of Gadosol is 0.2 mL/kg (0.1 mmol/kg) body weight administered as an intravenous bolus injection, manually or by power injector, at a flow rate of approximately 2 mL/second for adults and 1- 2 mL/second for pediatric patients. Table 1 provides weight-adjusted dose volumes. To ensure complete injection of Gadosol the injection may be followed by normal saline flush. Contrast MRI can begin immediately following Gadosol injection.
For adult and pediatric patients (including term neonates), the recommended dose of Gadosol is 0.2 mL/kg (0.1 mmol/kg) body weight administered as an intravenous bolus injection, manually or by power injector, at a flow rate of approximately 2 mL/second for adults and 1- 2 mL/second for pediatric patients. Table 1 provides weight-adjusted dose volumes. To ensure complete injection of Gadosol the injection may be followed by normal saline flush. Contrast MRI can begin immediately following Gadosol injection.

In the real case of overdose, Gadosol can be removed from the body by haemodialysis (blood cleaning).

Store at 25°C; Should solidification occur in the vial because of exposure to the cold, Gadoteric Acid should be brought to room temperature before use. If allowed to stand at room temperature for a minimum of 90 minutes, Gadoteric Acid should return to a clear, colorless to yellow solution. Before use, examine the product to assure that all solids are redissolved and that the container and closure have not been damaged. Should solids persist, discard the vial.

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