Aristopin

The exact mode of action of Atropine Sulfate is attributed to the suppression of the progression of myopia. Muscarinic receptors are widely distributed in ocular tissues, with roles in ocular growth and development, as well as accommodation, recognized. Preclinical studies suggest that Atropine Sulfate acts via binding to the muscarinic receptors located on scleral fibroblasts and possibly in the retina, primarily the M1, M3 and M4 subtypes. This results in changes in the activity of cell signaling proteins and enzymes such as MEK-ERK-MAPK and transglutaminases, and possibly dopamine release, causing scleral remodeling or strengthening, leading to a reduction in axial length and vitreous chamber depth and consequently a suppression of myopia progression.

Atropine Sulfate should not be used with the following medications, because serious interactions may occur with Anticholinergics, Antiglaucoma agents, Potassium Citrate, Potassium Supplements, Carbachol, Physostigmine or Pilocarpine & CNS medication.

Blurred vision, local irritation, follicular conjunctivitis, vascular congestion, oedema, exudate, contact dermatitis, eczematous dermatitis, photophobia etc.

Atropine Sulphate may be systemically absorbed after ocular administration; however, signifcant efects on the fetus have not been reported. Systemically absorbed Atropine Sulphate is distributed into breast milk in very small amounts. It may cause adverse efects, such as rapid pulse, fever, or dry skin, in nursing infant of mothers using ophthalmic Atropine.

Atropine Sulfate should not be used in children who have previously had severe systemic reaction to Atropine Sulfate. An increased susceptibility to Atropine Sulfate has been reported in children with Down’s syndrome, spastic paralysis, or brain damage; therefore Atropine Sulfate should be used with great caution in these patients. It is recommended that regular eye health clinical reviews are conducted if long term treatment is planned, including the monitoring of anterior segment development, IOP, retinal health and myopia progression. This eye drops should not be used in children less than 4 years of age.

Mydriatic and Cycloplegic agents

Flush the eye with water and seek emergency medical attention. Symptoms of a atropine ophthalmic overdose include headache, fast heartbeat, dry mouth and skin, unusual drowsiness, and fushing.