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Azonam

Azonam
- IM/IV Injection
Generic name: Aztreonam
1 gm/5 ml
Manufactured by: Incepta Pharmaceuticals Ltd.

1 gm vial: ৳ 400.00

Alternative Brand

Urinary tract infection

Aztreonam is indicated in the treatment of the following infections caused by susceptible aerobic Gram-negative micro-organisms

Urinary tract infections: Pyelonephritis, cystitis (initial and recurrent) and asymptomatic bacteriuria (including those due to pathogens resistant … Read more

Aztreonam is indicated in the treatment of the following infections caused by susceptible aerobic Gram-negative micro-organisms

Urinary tract infections: Pyelonephritis, cystitis (initial and recurrent) and asymptomatic bacteriuria (including those due to pathogens resistant to the aminoglycosides, cephalosporins or penicillins).
Gonorrhea: Acute uncomplicated urogenital or anorectal infections.
Lower respiratory tract infections: Including pneumonia, bronchitis and lung infections in patients with cystic fibrosis.
Skin and soft tissue infections: Postoperative wounds, ulcers and burns.
Meningitis: Caused by Haemophilusinfluenzae or Neisseria meningitidis.
Gynecological infections: Pelvic Inflammatory Disease (PID), endometritis and pelvic cellulitis.
Intra-abdominal infections: Peritonitis.
Bacteremia/ septicemia: Septicemia caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa,Proteus mirabilis, Serratia marcescens and Enterobacter species.
Bone and joint infections: Osteomyelitis,septic arthritis.

Aztreonam is also indicated for adjunctive therapy to surgery in the management of infections caused by susceptible organisms. Patients with serious Pseudomonas infections may benefit from concurrent use of Aztreonam and an aminoglycoside because of their synergistic action.

Aztreonam is a synthetic bactericidal monobactam antibiotic. It inhibits bacterial cell wall synthesis by blocking peptidoglycan crosslinking. The inhibition of bacterial cell wall synthesis occurs due to a high affinity of Aztreonam for penicillin binding protein 3 (PBP3). By binding to PBP3, Aztreonam inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. It is possible that Aztreonam interferes with an autolysin inhibitor.
Concomitant administration of probenecid or furosemide and Aztreonam causes clinically insignificant increases in the serum levels of Aztreonam.
Local reactions such as phlebitis/thrombophlebitis following IV administration and discomfort/swelling at the injection site following IM administration may occur. Systemic reactions like diarrhea, nausea and/or vomiting, and rash may occur. Other side effects include anaphylaxis, angioedema, bronchospasm, pancytopenia, neutropenia, thrombocytopenia, anemia, eosinophilia, leukocytosis, thrombocytosis, abdominal cramps, dermatitis, urticaria, pruritus, hypotension, flushing, seizure, weakness, headache, fever, malaise may occur.
Pregnancy Category B. Aztreonam crosses the placenta and enters the fetal circulation. So it should be used during pregnancy only if the potential benefit justifies the potential risk.

Aztreonam is excreted in breast milk in concentrations that are less than 1% of concentrations determined in simultaneously obtained maternal serum. Temporary discontinuation of nursing is recommended.

In patients with impaired hepatic or renal function, appropriate monitoring is recommended during therapy.
Renal Impairment: In patients with impaired renal function, the normal recommended initial dose should be given. This should be followed by maintenance doses as below:

Creatinine clearance (10–30 ml/min): Maintenance dose is half of the initial dose.

Creatinine clearance (Less than 10 ml/min): One quarter of the initial dose.

The normal dose interval should not be altered. In patients on haemodialysis, a supplementary one eighth of the initial dose should be given after each dialysis.

Recommended for children of one week and older. Aztreonam for injection should be administered intravenously to pediatric patients with normal renal function. There are insufficient data regarding intramuscular administration to pediatric patients or dosing in pediatric patients with renal impairment.

Other beta-lactam Antibiotics
If necessary, Aztreonam may be cleared from the serum by hemodialysis and/or peritoneal dialysis.
Store in a cool & dry place, protected from light & moisture. Keep all medicines out of reach of children.

Alternative Brand Names

IM/IV Injection
Azactum
Aztreonam
1 gm/5 ml
Drug International Ltd.

1 gm vial: ৳ 400.00

All Medicine