10000 IU vial: ৳ 4,046.00
L-Asparginase injection is indicated as a component of a multi-agent chemotherapeutic regimen for the treatment of patients with acute lymphoblastic leukemia (ALL).
The mechanism of action of L-Asparginase is thought to be based on the selective killing of leukemic cells due to the depletion of plasma asparagine. Some leukemic cells are unable to synthesize asparagine due to a lack of asparagine synthetase and are dependent on an exogenous source of asparagine for survival. Depletion of asparagine, which results from treatment with the enzyme L asparaginase, kills the leukemic cells. Nomial cells, however, are less affected by the depletion due to their ability to synthesize asparagine.
L-Asparginase for Injection contains the enzyme L-Asparagine Amidohydrolase, type EC-2. Asparginase is not absorbed from the GI Tract and hence must be administered IM or IV. The IM route maintains efficacy and has not been shown to be less immunogenic. When given by the IM route, not more than 2 ml of the solution should be given at one injection site. L-Asparginase activity is expressed in terms of International Units according to the recommendation of the International Union of Biochemistry. One International Unit of Asparaginase is defined as the amount of enzyme required to generate 1 µmol of ammonia per minute at pH 7.3 and 37°C. The specific activity of Asparginase is at least 225 international Units per milligram of protein. L-Asparginase for Injection is provided as a sterile, white lyophilized plug or powder. Each vial contains 10,000 International Units or 5,000 International Units of Lyophilized L-Asparginase for Injection.
Drug/laboratory Test Interaction: L-Asparginase has been reported to interfere with the interpretation of thyroid function tests by producing a rapid and marked reduction in serum concentrations of thyroxine-binding globulin within two days after the first dose. Serum concentrations of thyroxine-binding globulin returned to pretreatment values within four weeks of the last dose of L-Asparglnase.
The following serious adverse reactions occur with L-Asparginase treatment:
- Anaphylaxis and serious allergic reactions
- Serious thrombosis
- Pancreatitis
- Glucose intolerance
- Coagulopathy
- Hepatotoxicityandabnonnal liver function
The most common adverse reactions with L-Asparginase are allergic reactions (including anaphylaxis), hyperglycemia, pancreatitis, central nervous system (CNS) thrombosis, coagulopathy, hyperbilirubinemia, and elevated transaminases.
Nursing Mothers: It is not known whether L-Asparginase is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from L-Asparginase, a decision should be made to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.