Suma

Sumatriptan is indicated for acute treatment of migraine with or without aura in adults.

Limitations of Use:

• Use only if a clear diagnosis of migraine headache has been established.
• Not indicated for the prophylactic therapy of migraine attacks.
• Not indicated for the treatment of cluster headache.

Sumatriptan Nasal Spray is an aqueous suspension of microfine Sumatriptan BP 10 mg for topical administration to the nasal mucosa by means of a metering, atomizing spray pump. Sumatriptan binds with high affinity to human cloned 5 HT_1B/1D receptors. Sumatriptan presumably exerts its therapeutic effects in the treatment of migraine headache through agonist effects at the 5 HT_1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system, which result in cranial vessel constriction and inhibition of pro-inflammatory neuropeptide release.

With Medicine: Sumatriptan nasal spray is contraindicated with Ergot-Containing Drugs, Monoamine Oxidase-A Inhibitors, Other 5-HT1 Agonists and Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors.

With food and others: No interaction with foods.

Common side effects: Unusual or unpleasant taste in the mouth; pain, burning, numbness, or tingling in the nose or throat; runny or stuffy nose after using the nasal medicine.

Rare side effects: Anxiety, burning sensation, discomfort of the nasal cavity and throat, general feeling of illness or tiredness & vision changes.

There are no adequate and well-controlled studies in pregnant women and lactating mothers.

• Myocardial ischemia/infarction and Prinzmetal’s angina: Perform cardiac evaluation in patients with multiple cardiovascular risk factors
• Arrhythmias: Discontinue Sumatriptan if occurs
• Chest/throat/neck/jaw pain, tightness, pressure, or heaviness: Generally, not associated with Myocardial Ischemia; evaluate for coronary artery disease in patients at high risk
• Cerebral hemorrhage, subarachnoid hemorrhage, and stroke: Discontinue Sumatriptan if occurs
• Gastrointestinal ischemia and reactions, peripheral vasospastic reactions: Discontinue Sumatriptan if occurs
• Medication overuse headache: Detoxification may be necessary
• Serotonin syndrome: Discontinue Sumatriptan if occurs
• Increase in blood pressure: Hypertensive crisis can occur
• Hypersensitivity reactions: Angioedema and anaphylaxis can occur
• Seizures: Use with caution in patients with epilepsy or a lowered seizure threshold
• Local irritation: Burning and abnormal taste can occur

5-HT Agonists

No specific data is available on the overdose of Sumatriptan 10 mg nasal spray.

Store between 20°C-25°C temperature. Do not store in the refrigerator or freezer. Do not test before use